Friederike Grandke

The paper profiles PBMCs from PD patients and controls using single-cell RNA sequencing after ex vivo activation, finding sex-convergent CD8+ T cell exhaustion associated with disease.

PBMCpedia harmonizes PBMC scRNA-seq data across 24 studies, providing standardized preprocessing, batch correction, and cell type annotation for reproducible immune profiling.

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

ROSMAP-Compass harmonizes 22 million single nuclei from the ROSMAP cohort to create an AI-ready resource for Alzheimer's disease research.

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.