Matthias Flotho

This study identifies sex-dimorphic molecular responses to microglial depletion in aged mice, highlighting differences in transcriptional and proteomic changes between males and females.

The paper identifies age-related miRNA deregulation patterns in aging rhesus macaques, highlighting tissue and sex-specific changes and cross-species conservation.

PBMCpedia harmonizes PBMC scRNA-seq data across 24 studies, providing standardized preprocessing, batch correction, and cell type annotation for reproducible immune profiling.

This paper uses VINE-seq to create a vascular transcriptomic atlas in Alzheimer's disease, revealing transcriptional changes in vascular cells and identifying angiopoietin signaling as a key dysregulated pathway.

ROSMAP-Compass harmonizes 22 million single nuclei from the ROSMAP cohort to create an AI-ready resource for Alzheimer's disease research.

SingleRust improves single-cell RNA sequencing analysis by optimizing memory and performance, enabling analysis of 30 million cells on standard infrastructure.

The paper uses single-cell spatial transcriptomics to analyze brain samples from neurodegenerative diseases and COVID-19, identifying disease-specific transcriptional patterns and microenvironmental changes.

The paper constructs a multimodal brain cell atlas of adult macaques across their lifespan, revealing aging-related molecular changes and identifying aging hotspots and regulatory loci.

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.