Viktoria Wagner

This study identifies sex-dimorphic molecular responses to microglial depletion in aged mice, highlighting differences in transcriptional and proteomic changes between males and females.

The paper uses plasma proteomics to estimate biological age of multiple cell types and links aging signatures to disease risk and mortality across 60,000 individuals.

ROSMAP-Compass harmonizes 22 million single nuclei from the ROSMAP cohort to create an AI-ready resource for Alzheimer's disease research.

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

The paper creates a spatio-temporal miRNA atlas in mice, identifying age-related miR-155-5p increase driven by microglia, independent of sex.

The paper uses single-cell spatial transcriptomics to analyze brain samples from neurodegenerative diseases and COVID-19, identifying disease-specific transcriptional patterns and microenvironmental changes.

This study uses spatial transcriptomics to compare aging and infection effects across multiple organs in mice, identifying shared gene expression patterns in immune pathways.