Eleanor Elgood Hunt

The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.

The paper introduces TT-TSS-seq, a method to map and quantify transcription start sites from nascent transcripts, revealing multiple initiation sites per gene and detecting unstable transcripts.

The paper shows DNA supercoiling affects alternative TSS selection in yeast, impacting 600 genes and altering TSS usage near and within open reading frames.