Jenie Hannah Johnkingsly Jebaraj

The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.

The paper uses enhancer scrambling to study a super-enhancer of the OTX2 gene, finding that a single DNase I hypersensitive site predominantly controls its expression.