Lineage-specific retrotransposon co-option reveals a conserved ASH2L isoform as an epigenetic primer of developmental gene promoters
Eleanor Elgood Hunt, Claudia Vivori, Richard Mitter, Jenie Hannah Johnkingsly Jebaraj, Vedis Agnadottir, M. Joaquina Delàs, Eduardo Serna-Morales, Thomas J.R. Frith, Mark Skehel, Alberto Elósegui-Artola, James Briscoe, Folkert Jacobus van Werven
The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.
bioRxiv · May 27, 2026 · PreprintMolecular Biology