Shawn T. O’Neil

Phenomics Assistant is a chat-based interface that uses LLMs to query the Monarch knowledge graph, improving reliability for non-expert users to explore disease-gene-phenotype relationships.

The paper identifies cis-regulatory determinants of tissue-specific gene expression in Arabidopsis thaliana by analyzing TSS-seq, OC-seq, and RNA-seq data, finding that TSS-proximal TF binding sites are more important than distal chromatin regions.