Hiroki Okumura

ROCKET refines AlphaFold2 predictions against crystallographic, cryo-EM and cryo-ET data by gradient descent on MSA cluster profiles, capturing loop flips and domain shifts without retraining.

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

The paper shows Uromodulin forms salt-dependent velcro-like sheets that interact with UPEC pili, revealing structural mechanisms for UTI protection.

ExDyn is a deep generative model that estimates single-cell transcriptome dynamics influenced by extrinsic factors, showing improved accuracy over existing methods.