Norio Ozaki

Distinct effects of nonselective Rho-kinase inhibitor fasudil and selective Rho-kinase 2 inhibitor KD025 on serotonin and dopamine release in the nucleus accumbens of mice

This study compares the effects of fasudil and KD025 on serotonin and dopamine release in the nucleus accumbens of mice, finding distinct roles for Rho-kinase 1 and 2 in neurotransmitter regulation.

Antipsychotic-like effects of the selective Rho-kinase 2 inhibitor KD025 in genetic and pharmacological mouse models of schizophrenia

This study shows that the selective ROCK2 inhibitor KD025 has antipsychotic-like effects and fewer side effects in schizophrenia models.

Cortical excitatory and inhibitory neuron deficits may underlie the cognitive and social impairments in a mouse model of schizophrenia with exonic Reln deletion

This paper investigates the role of Reelin in schizophrenia by analyzing a mouse model with exonic Reln deletion, finding deficits in excitatory and inhibitory neurons and suggesting therapeutic potential for Reelin replacement.

Twinfilin-1 phosphorylation in reelin signaling regulates actin dynamics and spine development

This study identifies Twinfilin-1 phosphorylation as a key component of reelin signaling that regulates actin dynamics and spine development in neurons.

MeCP2 controls dendritic morphogenesis via miR-199a-mediated Qki downregulation

This study identifies the MeCP2/miR-199a/Qki axis as critical for dendritic development and shows its dysregulation contributes to dendritic pathology in Rett syndrome.

Inferring extrinsic factor-dependent single-cell transcriptome dynamics using a deep generative model

ExDyn is a deep generative model that estimates single-cell transcriptome dynamics influenced by extrinsic factors, showing improved accuracy over existing methods.

Biallelic null variants in PNPLA8 cause microcephaly through the reduced abundance of basal radial glia

This study identifies biallelic PNPLA8 variants causing microcephaly by reducing basal radial glia in cerebral organoids and disrupting phospholipid metabolism.

Genome Wide Study of Tardive Dyskinesia in Schizophrenia

This study performs the largest GWAS of tardive dyskinesia, identifies novel and suggestive loci, and explores polygenic risk and biological pathways.

A Network of Networks Approach for Modeling Interconnected Brain Tissue-Specific Networks

The paper introduces a Network of Networks framework and GOSPEL algorithm to model interconnectivity between brain-specific functional networks and identify autism-associated genetic structures.

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

High genetic loading for schizophrenia predicts poor response to lithium in patients with bipolar disorder: A polygenic score and cross-trait genetic analysis

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.