Author

Michael Salsaa

Dalhousie UniversityORCID 0000-0001-6247-6336Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Gregory D. FairniD· 2 shared Brian RaughtiD· 1 shared Bryan C. DickinsoniD· 1 shared Charneal L. DixoniD· 1 shared Haggag S Zein· 1 shared Haggag S. Zein· 1 shared Huu Tram A Huynh· 1 shared Jonathan R. St‐GermainiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Gregory D. FairnORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMar 25, 2026

Quaternary structure and activity of glutamate dehydrogenase are regulated by reversible S-palmitoylation and mitochondrial acyl-protein thioesterases.

Michael Salsaa, Huu Tram A Huynh, Charneal L. Dixon…·Gregory D. Fairn

This study identifies S-palmitoylation as a reversible regulatory mechanism for GDH, affecting its quaternary structure and enzymatic activity through cysteine modifications.

DOI 10.64898/2026.03.25.714181

humanproteomics

𝕏 PostBluesky

Cancer BiologyBiochemistry and Cell BiologyPeer-reviewedJan 1, 2026

Acyl-protein thioesterase 1 (LYPLA1) activity promotes the growth of MDA-MB-468 triple-negative breast cancer cells.

Michael Salsaa, Mahtab Tavasoli, Haggag S Zein…·Gregory D. Fairn

This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.

DOI 10.1139/bcb-2025-0446

humanproteomics

𝕏 PostBluesky