Cancer BiologyBiochemistry and Cell BiologyPeer-reviewed
Acyl-protein thioesterase 1 (LYPLA1) activity promotes the growth of MDA-MB-468 triple-negative breast cancer cells.
Michael Salsaa, Mahtab Tavasoli, Haggag S Zein…·Gregory D. Fairn
This study identifies APT1/LYPLA1 as a context-dependent vulnerability in triple-negative breast cancer by showing its role in regulating cell proliferation through de-S-acylation of cell-cycle and mitochondrial proteins.
DOI 10.1139/bcb-2025-0446