Author

Ann‐Sofie Jemth

Science for Life LaboratoryORCID 0000-0002-7550-1833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Dante RotiliiD· 1 shared Eri van Berkum· 1 shared Fredrik KlingegårdiD· 1 shared Gabriel Tidestav· 1 shared Jonas Malmström· 1 shared Julia EklundiD· 1 shared Maria Joao Almeida A Silva PiresiD· 1 shared Massimiliano GaetaniiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Dante RotiliORCID

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1 paper

Recent·Most cited

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

Seher Alam, Maria Joao Almeida A Silva Pires, Gabriel Tidestav, Ann‐Sofie Jemth, Julia Eklund, Fredrik Klingegård, Rémi Caraballo, Massimiliano Gaetani, Dante Rotili, Siebe van den Elzen, Eri van Berkum, Olov A. Wallner, Thomas P. Gustafsson, Jonas Malmström, Per I. Arvidsson, , Mikael Altun

This paper introduces a cell-based platform to assess PROTACs targeting NUDT5, identifying a VHL-dependent degrader despite poor in vitro binding and showing CRBN-dependent degraders are ineffective.

bioRxiv · Jun 13, 2025 · PreprintBiochemistry