Dante Rotili

m6A RNA methylation modulates Zika virus infection by regulating serine proteases in Aedes albopictus

This study identifies m6A RNA methylation as an antiviral mechanism in mosquito cells by regulating serine proteases that influence Zika virus replication.

A cell-based degrader assessment platform facilitates discovery of functional NUDT5 PROTACs

This paper introduces a cell-based platform to assess PROTACs targeting NUDT5, identifying a VHL-dependent degrader despite poor in vitro binding and showing CRBN-dependent degraders are ineffective.

Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity

This study uses CeTEAM biosensors to profile PARP inhibitor selectivity at the single-cell level, revealing PARP1 and PARP2 selectivity patterns and the role of HPF1 in drug binding.

The inhibitory effects of Remodelin on murine myoblasts differentiation

This study investigates how Remodelin, a Nat10 inhibitor, affects myoblast differentiation in murine and rat cells, showing impaired myotube formation and maturation.

Quinoline-based compounds can inhibit diverse enzymes that act on DNA

This study identifies quinoline-based compounds that inhibit DNA methyltransferases and other DNA-targeting enzymes, with compound 11 inducing DNA damage response in cancer cells.

M6A reduction relieves FUS-associated ALS granules

The paper shows that reducing m6A content via METTL3 knock-down decreases FUS-associated ALS granules in cell models and patient-derived fibroblasts.

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.