Maria Joao Almeida A Silva Pires

The paper introduces a modular lentiviral system for multiplexed gene perturbation and functional analysis, showing that ER+ breast cancer cells rely on AR, ER, and PR for in vivo growth.

This paper introduces a cell-based platform to assess PROTACs targeting NUDT5, identifying a VHL-dependent degrader despite poor in vitro binding and showing CRBN-dependent degraders are ineffective.

This study uses CeTEAM biosensors to profile PARP inhibitor selectivity at the single-cell level, revealing PARP1 and PARP2 selectivity patterns and the role of HPF1 in drug binding.