Fariba Behbod

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

This study shows that sEVs and their miRNAs, particularly miR-205, promote DCIS progression and that inhibiting sEV release or re-expressing miR-205 can reduce invasive properties in DCIS cells.

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.