Alastair Mark Thompson

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

The paper establishes a biobank of TNBC patient-derived xenografts with treatment-naive and longitudinal samples to study chemoresistance and metastasis.

The paper introduces wellDA-seq, a method to co-profile genome and epigenome in single cells, revealing genetic hardwiring and epigenetic plasticity in breast cancer.

This study develops scNanoSeq to detect somatic mutations in single tumor cells, revealing subtype-specific evolutionary patterns and a reprogramming and critical mutation co-timing model in breast cancer.

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

The paper uses genomic profiling to show that some invasive breast cancers are clonally unrelated to their preceding DCIS, suggesting DCIS may act as both a precursor and independent risk factor.

This paper introduces CellTrek, a computational method that integrates scRNA-seq and spatial transcriptomics data to map single cells in tissues, showing accurate spatial organization in mouse and human tissues.