Andrew K. Godwin

Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

Cellular stemness identifies high-risk ductal carcinoma in situ and offers a therapeutic interception opportunity

This study identifies stemness features in luminal hormone-responsive cells within DCIS that correlate with invasive progression and shows that targeting FOXA1 reduces tumor growth.

Keratin 5 marks cancer-propagating cells sustained by an osteopontin-producing niche in high-grade serous ovarian carcinoma

This study identifies KRT5-expressing cells as cancer-propagating cells in HGSC that depend on an OPN-producing niche for survival and chemoresistance.

Comparative single-cell atlases reveal injury-driven tubal epithelial regeneration as a window for ovarian carcinoma initiation

The paper compares single-cell transcriptomes of mouse and human tubal epithelium to show injury-driven regeneration in humans may contribute to ovarian cancer initiation.

A live tumor fragment platform to assess immunotherapy response in core needle biopsies while addressing challenges of tumor heterogeneity

This paper introduces a live tumor fragment platform to assess immunotherapy response in core needle biopsies, showing it can detect T-cell responses and mitigate tissue heterogeneity challenges.

Large-scale genome-wide association study of 398,238 women unveils seven novel loci associated with high-grade serous epithelial ovarian cancer risk

This study identifies seven novel genetic loci associated with high-grade serous ovarian cancer risk using a large-scale GWAS and develops polygenic scores for improved risk prediction.

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

This study identifies 32 new breast cancer susceptibility loci through GWAS, with associations varying by tumor subtype and genetic correlations among subtypes.