Ioannis Mantas

This study maps cell-type specific transcriptional changes in the parkinsonian striatum across species, identifying vulnerable and resilient cell types.

The paper identifies Anxa1+ dopamine neurons as vulnerable in prodromal Parkinson's disease, linking their dysfunction to bradykinesia and procedural motor learning impairments.

The paper identifies a striosomal ACB projection to the Esr1+ LHA-LHb pathway that drives compulsive seeking behaviors through aversive signaling.

The paper constructs a single nuclei RNA sequencing atlas of mouse midbrain dopamine neurons, revealing continuous molecular diversity and identifying gene expression patterns linked to vulnerability in a Parkinsonism lesion model.