Thomas Perlmann

This study identifies Sox9 and Nfi transcription factors as regulators of G0 entry and ependymal maturation in midbrain dopamine progenitors, with effects dependent on developmental timing.

The paper constructs a single nuclei RNA sequencing atlas of mouse midbrain dopamine neurons, revealing continuous molecular diversity and identifying gene expression patterns linked to vulnerability in a Parkinsonism lesion model.

This study shows that PRC2-mediated repression is essential for maintaining identity and function of dopaminergic and serotonergic neurons, with loss leading to behavioral deficits.

This study shows that while most hypothalamic neurons develop normally without the H3K27me3 epigenetic mark, specific neuronal subtypes are sensitive to its loss.

The paper uses scRNA-seq to analyze graft composition in a Parkinson’s disease cell therapy model, revealing differences between human stem cell-derived and fetal tissue grafts.