Laura Lahti

This study identifies Sox9 and Nfi transcription factors as regulators of G0 entry and ependymal maturation in midbrain dopamine progenitors, with effects dependent on developmental timing.

The paper constructs a single nuclei RNA sequencing atlas of mouse midbrain dopamine neurons, revealing continuous molecular diversity and identifying gene expression patterns linked to vulnerability in a Parkinsonism lesion model.

The paper identifies a transcription factor network involving Gata2, Nkx2-2, and Skor2 that regulates the development of midbrain GABAergic neurons associated with REM sleep regulation.