Roman E. Reggiardo

The paper identifies autoantibody hotspots on the XIST RNP complex in female-biased autoimmune diseases and links them to clinical outcomes.

This paper identifies an age-specific platelet differentiation pathway from hematopoietic stem cells that contributes to thrombosis and platelet hyperreactivity in aging.

This study investigates how KRAS(G12C) mutations affect transposable element RNA expression in 3D lung cancer spheroids, finding mutation-specific TE RNA dysregulation and activation of Alu-derived RNAs with innate immunity genes.

This study identifies specific extracellular RNA signatures secreted by mutant KRAS(G12C) lung adenocarcinoma cells that correlate with patient survival.

This paper validates a pancreatic cancer detection test using 5-hydroxymethylation signatures in cell-free DNA from patients with new-onset diabetes, showing high specificity and moderate sensitivity.

This study identifies how mutant KRAS reprograms the noncoding transcriptome, upregulating repetitive noncoding RNAs and inducing IFN-stimulated genes through epigenetic and RNA-based mechanisms.