Autoantibody hotspots reveal origin and impact of immunogenic XIST ribonucleoprotein complex
Bingyu Yan, Jinwoo Lee, Suhas Srinivasan, Quanming Shi, Diana R. Dou, Srijana Davuluri, Swarna Nandyala, Adrianne Woods, Gwen Leatherman, Yanding Zhao, Roman E. Reggiardo, Manasi Sawant, Hawa Racine Thiam, Ami A. Shah, David Franklin Fiorentino, , Howard Y. Chang
The paper identifies autoantibody hotspots on the XIST RNP complex in female-biased autoimmune diseases and links them to clinical outcomes.
bioRxiv · Jan 16, 2025 · PreprintImmunology