Hikari Yoshitane

This study identifies nardilysin as a modulator of the mammalian circadian clock by selectively regulating PER2 function, leading to altered circadian rhythms in mice.

This study shows that minocycline prevents early aging phenotypes in Rp58 hetero-KO mice by mitigating DNA damage and cognitive decline.

This study shows that mutating a PER2 phosphodegron in mice leads to longer circadian periods and altered molecular stability.

This study shows that SIK3 regulates circadian rhythms in mice by destabilizing PER2 protein through phosphorylation.