Akanksha Sharma

The paper identifies Arg80 as a key regulator of proteostasis in S. cerevisiae, showing its role in mitigating proteotoxic stress through interactions with arginine metabolism and stress response pathways.

This study shows that adaptive evolution in yeast increases ERAD capacity to improve thermotolerance by enhancing proteostasis under thermal stress.

The paper identifies that reducing mitochondrial protein import capacity alleviates cytosolic protein misfolding fitness defects in yeast by enhancing proteostasis.