Kausik Chakraborty

This paper identifies phospholipids that regulate lipid transfer through CETP by enabling a novel 'gliding' mechanism, revealing their critical role in lipid movement and providing new therapeutic insights.

The paper identifies Arg80 as a key regulator of proteostasis in S. cerevisiae, showing its role in mitigating proteotoxic stress through interactions with arginine metabolism and stress response pathways.

This study shows that adaptive evolution in yeast increases ERAD capacity to improve thermotolerance by enhancing proteostasis under thermal stress.

The paper identifies that reducing mitochondrial protein import capacity alleviates cytosolic protein misfolding fitness defects in yeast by enhancing proteostasis.

The paper shows that eukaryotic Hsp60/10 systems with dicarboxylic acids mimic GroEL/ES activity in vitro, altering the folding landscape specifically for eukaryotic chaperonins.

The paper shows that GroEL/ES buffers entropic traps in protein folding pathways introduced by mutations, which are rescued by the chaperonin, while it can also edit non-native contacts but is not utilized in vivo.

The paper investigates cellular responses to proteostasis impairments in yeast, finding that transcriptional responses often fail to restore proteostasis and that over-expression of alternative machineries can partially compensate for gene deletions.

dms2dfe reduces noise and performs downstream analyses of Deep Mutational Scanning data to identify selection pressures and molecular constraints.