Devi Prasanna Dash

Laboratory adaptive evolution of thermotolerance is linked to the evolution of a robust proteostasis in S. cerevisiae

This study shows that adaptive evolution in yeast increases ERAD capacity to improve thermotolerance by enhancing proteostasis under thermal stress.

Fitness defects due to cytosolic protein misfolding in S. cerevisiae can be alleviated by decreasing mitochondrial protein import capacity

The paper identifies that reducing mitochondrial protein import capacity alleviates cytosolic protein misfolding fitness defects in yeast by enhancing proteostasis.

Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks

The paper investigates cellular responses to proteostasis impairments in yeast, finding that transcriptional responses often fail to restore proteostasis and that over-expression of alternative machineries can partially compensate for gene deletions.