Author

Nicole Borth

Austrian Centre of Industrial Biotechnology (Austria)ORCID 0000-0001-6324-9338Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alexander Molin· 2 shared Antonino NapoleoneiD· 2 shared David E. RuckerbaueriD· 2 shared Diana SzéliováiD· 2 shared Federico De MarcoiD· 2 shared Ivy Rose SebastianiD· 2 shared Jürgen ZanghelliniiD· 2 shared Lovro KrameriD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMolecular Biology

Alexander Molin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular BiologyMolecular Therapy AdvancesPeer-reviewedJan 27, 2026

Overcoming lentiviral delivery limitations in hard-to-transduce suspension cells for genome-wide CRISPR screening

Antonino Napoleone, Ivy Rose Sebastian, Federico De Marco…·Nicole Borth

This study improves lentiviral transduction efficiency in suspension cells for CRISPR screening by optimizing protocols and analyzing integration patterns.

3 citationstop 4%

humanCRISPR screen

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BioinformaticsbioRxivPreprintJan 5, 2026

MCBO: Mammalian Cell Bioprocessing Ontology, A Hub-and-Spoke, IOF-Anchored Application Ontology

Kimberly Robasky, James Morrissey, Markus Riedl…·Nathan E. Lewis

MCBO provides a standardized ontology for mammalian cell bioprocessing data to enable harmonization and querying of complex biomanufacturing datasets.

DOI 10.64898/2026.01.05.697007

statistical modeldatabase / resource

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Cell BiologyMetabolic EngineeringPeer-reviewedAug 19, 2025

A genome-scale CRISPR deletion screen in Chinese Hamster Ovary cells reveals essential regions of the coding and non-coding genome

Federico De Marco, Ivy Rose Sebastian, Antonino Napoleone…·Nicole Borth

This study uses a genome-scale CRISPR deletion screen in CHO cells to identify essential genomic regions, revealing 427 previously unannotated or poorly characterized regions critical for cell survival.

9 citations

mousegenetic perturbation / CRISPR

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Systems BiologyPLoS Computational BiologyPeer-reviewedJun 11, 2021

Inclusion of maintenance energy improves the intracellular flux predictions of CHO

Diana Széliová, Jerneja Štor, Isabella Thiel…·Isabel Rocha

This study improves intracellular flux predictions in CHO cells by incorporating maintenance energy, enhancing accuracy for TCA cycle fluxes.

11 citations

mousebulk RNA-seq

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Systems BiologyBiotechnology JournalPeer-reviewedDec 19, 2020

Error propagation in constraint-based modeling of Chinese hamster ovary cells

Diana Széliová, Dmytro Iurashev, David E. Ruckerbauer…·Jürgen Zanghellini

This study examines how measurement errors and sampling frequency affect exchange rate accuracy and subsequent FBA predictions in CHO cells.

7 citations

mousemetabolomics

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