Elise J. Needham

This study conducts the first genome-wide association study of the phosphoproteome, identifying genetic variants influencing protein phosphorylation and linking them to disease traits.

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.