Daniel J. Fazakerley

Shape2Fate tracks and classifies exocytic and endocytic carriers in live cells using morphology-aware deep learning, revealing pathway-specific exo-endocytic coordination rules.

The paper identifies novel proteins that relocalize in adipocytes in response to insulin, highlighting their role in insulin signaling.

This study identifies factors affecting neural organoid generation by analyzing proteomic data and optimizes culture conditions to improve organoid quality.

This study develops a medium-throughput assay to assess leptin secretion and identifies mutations causing proteasomal degradation or reduced secretion.

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.