Felipe Ortega

This study develops an in vitro model of brain injury that recapitulates key features of injury and regeneration, enabling the study of glia-to-neuron reprogramming and stem cell dynamics.

This study identifies P2Y13 as a key regulator of NSC activation and division mode in the adult SEZ, distinguishing quiescent from activated NSCs and influencing self-renewal versus differentiation.

This study shows that forced Neurog2 expression in adult SEZ progenitors reprograms them to generate glutamatergic neurons, but not their postmitotic progeny.