Alessia Ferrarini

TurbOmics: a web-based platform for the analysis of metabolomics data using a multi-omics integrative approach

TurbOmics is a web-based platform that enables multi-omics integration of metabolomics, proteomics, and transcriptomics data, addressing limitations in metabolomics annotation and accessibility.

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

Modeling the acutely injured brain environment in vitro.

This study develops an in vitro model of brain injury that recapitulates key features of injury and regeneration, enabling the study of glia-to-neuron reprogramming and stem cell dynamics.

Activation of amino acid metabolic program in response to impaired glycolysis in cardiac HIF1 deficient mice

The paper investigates the effects of HIF1 deletion in cardiac progenitors, finding that it leads to impaired glycolysis and activation of an amino acid metabolic program without affecting heart development or function.

Metabolic reprogramming from glycolysis to amino acid utilization in cardiac HIF1α deficient mice.

This study investigates the effects of HIF1α deletion in cardiac progenitors during heart development, finding that HIF1 is dispensable for cardiac growth and reveals metabolic reprogramming toward amino acid utilization.