Small Molecule-Based Blockade of CD28 Suppresses T Cell Costimulation Across Cellular and Mucosal Co-culture Models
Saurabh Upadhyay, Valerij Talagayev, Sung‐Woo Cho…·Moustafa Tarek Gabr
This paper identifies a novel druggable site on CD28 and discovers 22VS, a small molecule inhibitor that suppresses T cell activation in co-culture models, with favorable pharmacokinetic properties.