Author
Heidelberg UniversityORCID 0000-0002-6103-9019Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Risa Suzuki, Jia Zheng Woo, Thomas Thumberger, Gero Hofmann, Joachim Wittbrodt, Tinatini Tavhelidse
This study develops a high-throughput optomotor response assay in medaka larvae to quantify visual traits and detect strain-specific differences.
PLoS ONE · Jun 28, 2024Peer-reviewedAnimal Behavior & Cognition
Sumit Kumar Vohra, Kristian J. Herrera, Tinatini Tavhelidse, Joachim Wittbrodt, Simon Knoblich, Ali Seleit, Alexander Aulehla, Jonathan Boulanger-Weill, Sydney Chambule, Ariel C. Aspiras, Cristina Santoriello, Mark C. Fishman, Hans‐Christian Hege, Daniel Baum, Florian Engert, Yasuko Isoe
The paper develops a multi-species brain atlas platform for comparative neuroscience in teleost fish, revealing species-specific neural structures and enabling gene expression and activity comparisons.
bioRxiv · Feb 14, 2024 · PreprintNeuroscience
Rebekka Medert, Thomas Thumberger, Tinatini Tavhelidse, Tobias Hub, Tanja Kellner, Yoko Oguchi, Sascha Dlugosz, Frank Zimmermann, Joachim Wittbrodt, Marc Freichel
This study demonstrates that 5-biotinylation of donor DNA enhances single-copy HDR in mice, achieving 19-26% efficiency in generating conditional alleles.
Nucleic Acids Research · Dec 12, 2022Peer-reviewedMolecular Biology
Thomas Thumberger, Tinatini Tavhelidse, José Arturo Gutiérrez Triana, Rebekka Medert, Alex Cornean, Bettina Welz, Marc Freichel, Joachim Wittbrodt
The paper introduces hei-tag, a tag that enhances CRISPR/Cas9 and base editor efficiency across multiple species and applications.
eLife · Mar 25, 2022Peer-reviewedGenetics
Tomas W. Fitzgerald, Ian Brettell, Adrien Léger, Nadeshda Wolf, Natalja Kusminski, Jack Monahan, Carl Barton, Cathrin Herder, Narendar Aadepu, Jakob Gierten, Clara Becker, Omar T. Hammouda, Eva Hasel, Colin Q. Lischik, Katharina Lust, , Felix Loosli
The paper introduces the Medaka Inbred Kiyosu-Karlsruhe (MIKK) panel, a vertebrate genetic resource for genotype-to-phenotype studies, enabling controlled experiments on complex traits.
Genome biology · Feb 21, 2022Peer-reviewedGenomics
Adrien Léger, Ian Brettell, Jack Monahan, Carl Barton, Nadeshda Wolf, Natalja Kusminski, Cathrin Herder, Narendar Aadepu, Clara Becker, Jakob Gierten, Omar T. Hammouda, Eva Hasel, Colin Q. Lischik, Katharina Lust, Natalia Sokolova, , Tomas W. Fitzgerald
The paper analyzes genomic and epigenomic variation in the MIKK panel using long-read sequencing and pan-genome graphs, revealing novel structural variants and methylation patterns.
Genome biology · Feb 21, 2022Peer-reviewedGenomics
Lucie Žílová, Venera Weinhardt, Tinatini Tavhelidse, Christina Schlagheck, Thomas Thumberger, Joachim Wittbrodt
The paper shows fish-derived organoids rapidly self-organize into retinal tissue, mimicking in vivo eye development, and highlights the impact of cell number and genetics on morphogenesis.
eLife · Jul 12, 2021Peer-reviewedDevelopmental Biology
José Arturo Gutierrez-Triana, Tinatini Tavhelidse, Thomas Thumberger, Isabelle Thomas, Beate Wittbrodt, Tanja Kellner, Kerim Anlaş, Erika Tsingos, Joachim Wittbrodt
The paper demonstrates that modifying the 5' ends of long dsDNA donors enhances HDR efficiency in Medaka, enabling efficient single-copy integration through monomeric donor conformation.
eLife · Aug 20, 2018Peer-reviewedGenetics