Alexander Aulehla

Cycles upon cycles - Temperature Scaling of Medaka Development

The paper investigates how temperature cycles affect medaka embryonic development, revealing temperature-insensitive spatial patterns that compensate for temperature-sensitive temporal oscillations.

Spatio-temporal visualisation and manipulation of endogenous Yap1 in medaka

This study develops a tool to visualize and manipulate endogenous Yap1 in medaka, revealing its dynamics during development and regeneration.

The limits of scaling in aggregation-driven patterning of cell collectives

The paper identifies cell aggregation as a key factor limiting the scaling of patterns in cell collectives and shows how system size affects pattern formation timing.

Quantitative mapping of heterochrony to species-specific phenotypes

The paper maps heterochrony in zebrafish and medaka using single-cell genomics, revealing cell-level timing shifts that contribute to species-specific phenotypes.

Heterochrony of axis segmentation underlies extreme morphogenesis in the Japanese eel

The paper shows that prolonged stemness in the tail of Japanese eels drives extreme axis segmentation through delayed Hox13 activation and sustained Oct4 expression.

Nonreciprocal synchronization in embryonic oscillator ensembles

The paper identifies non-reciprocal synchronization rules in embryonic oscillator ensembles using a novel experimental assay and develops a new coupling model called Rectified Kuramoto.

Modular control of time and space during vertebrate axis segmentation

This study shows that spatial and temporal control of axis segmentation in medaka fish are dissociable modules, identified through devQTL mapping and CRISPR validation.

Multi-species community platform for comparative neuroscience in teleost fish

The paper develops a multi-species brain atlas platform for comparative neuroscience in teleost fish, revealing species-specific neural structures and enabling gene expression and activity comparisons.

Glycolysis-Wnt signaling axis tunes developmental timing of embryo segmentation

This study shows glycolysis regulates the segmentation clock period in mouse embryos through a glycolysis-FBP-Wnt signaling axis, with FBP entraining Wnt oscillations.

Glycolytic flux-signaling controls mouse embryo mesoderm development

The paper shows that FBP, a glycolytic metabolite, affects mesoderm segmentation in mouse embryos by altering subcellular protein localization and Wnt-signaling.

Arnold tongue entrainment reveals dynamicalprinciples of the embryonic segmentation clock

The paper uses a coarse-grained theoretical-experimental approach to study the dynamics of the mouse embryonic segmentation clock, revealing its non-linear oscillator characteristics and long-term feedbacks.

Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach

This paper develops a simplified CRISPR/Cas9 method for endogenous protein tagging in medaka, achieving high efficiency and single-copy integration.