Lydia Blachowicz

The paper determines the cryo-EM structure of a Shaker K+ channel mutant and shows that voltage sensing domain activation induces a dynamic shift in the linker population equilibrium rather than directly pulling the gate open.

This paper designs and tests covalent kinase activity probes using computational methods and shows they target multiple kinases in live cells with distinct kinetics and conformations.

This study investigates the C-type inactivation mechanism in a Kv-like KcsA mutant, finding that the E71V mutation leads to a different structural conformation compared to wild-type KcsA.