Trayder Thomas

This study determines the structure of Kv channels bound to 4AP, showing it binds the closed state and enters via membrane-facing fenestrations, explaining its inhibitory mechanism.

The paper determines the cryo-EM structure of a Shaker K+ channel mutant and shows that voltage sensing domain activation induces a dynamic shift in the linker population equilibrium rather than directly pulling the gate open.

This paper designs and tests covalent kinase activity probes using computational methods and shows they target multiple kinases in live cells with distinct kinetics and conformations.