Chuan Ku

This study develops GVHoP, a machine learning tool that predicts eukaryotic hosts for giant viruses using genomic data, achieving high accuracy and revealing novel host associations across environments.

The paper reports a small mitochondrial genome from a planktonic foraminiferan, showing gene loss and accelerated evolution compared to other rhizarian mitogenomes.

This study uses single-cell dual proteomics to reveal cellular remodeling during photosymbiosis establishment in Paramecium and Chlorella.

This study shows that photosynthetic endosymbionts in Paramecium bursaria shape the host's daily gene expression patterns, with disrupted photosynthesis reverting these patterns to an aposymbiotic state.

The paper investigates carbon transfer between Paramecium bursaria and its Chlorella symbionts, finding host-to-symbiont carbon transfer rather than the previously assumed algal-to-host direction.

The paper identifies Cpe1, an interbacterial cysteine protease toxin from E. coli, which inhibits bacterial growth by cleaving type II DNA topoisomerases GyrB and ParE, disrupting DNA replication and chromosome segregation.

The paper identifies cathepsin X as a conserved cell death protein in algae involved in responses to environmental stress through transcriptome analysis and mutant studies.

The paper investigates the life cycle and morphogenetic differentiation of decoupled cells in O. huxleyi, showing they can revert to calcified form without viral pressure and exhibit distinct transcriptomic and ultrastructural features.

This study uses haplotype-aware multiomics to uncover the regulatory mechanisms behind life-cycle differentiation in Gephyrocapsa huxleyi.