Author

Chia-En Tsai

Institute of Molecular Biology, Academia SinicaORCID 0000-0003-0447-2286Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Po-Yin CheniD· 2 shared See‐Yeun TingiD· 2 shared Yung-Chih CheniD· 2 shared Chao-Yuan Hu· 1 shared Chih‐Wen YangiD· 1 shared Chuan KuiD· 1 shared Feng-Qi WangiD· 1 shared Ing‐Shouh HwangiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Po-Yin ChenORCID

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2 papers

Recent·Most cited

MicrobiologyPLoS BiologyPeer-reviewedMay 27, 2025

An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE

Pin-Yi Song, Chia-En Tsai, Yung-Chih Chen…·See‐Yeun Ting

The paper identifies Cpe1, an interbacterial cysteine protease toxin from E. coli, which inhibits bacterial growth by cleaving type II DNA topoisomerases GyrB and ParE, disrupting DNA replication and chromosome segregation.

8 citations

E. coliproteomics

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MicrobiologyThe EMBO JournalPeer-reviewedMar 10, 2025

Surface-mediated Bacteriophage Defense Incurs Fitness Tradeoffs for Interbacterial Antagonism

Chia-En Tsai, Feng-Qi Wang, Chih‐Wen Yang…·See‐Yeun Ting

The paper shows that phage resistance in Salmonella enterica leads to fitness loss when co-cultured with competitor bacteria due to LPS deficiency and increased susceptibility to T6SS.

12 citations

bacteria (other)experimental assay

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