Christian Thiel

KG-Bench benchmarks graph neural networks for drug repurposing using the Open Targets dataset, finding TransformerConv achieves the highest performance.

The paper establishes an auxin-inducible system to acutely knock down Pmm2 protein in medaka, mimicking hypomorphic mutations seen in PMM2-CDG patients.

The paper models a hypo-N-glycosylation disorder in medaka fish, showing reduced N-glycan abundance and retinal degeneration, with mRNA rescue restoring viability.