Kaisa Pakari

The paper establishes an auxin-inducible system to acutely knock down Pmm2 protein in medaka, mimicking hypomorphic mutations seen in PMM2-CDG patients.

This paper introduces an approach called 'inception' that allows base editing at previously inaccessible sites by generating new PAM sequences through sequential combinatorial base editing.

This paper introduces Mandi, a novel chemical inducer of protein proximity, and demonstrates its use in cell culture and living organisms for protein manipulation.

The paper models a hypo-N-glycosylation disorder in medaka fish, showing reduced N-glycan abundance and retinal degeneration, with mRNA rescue restoring viability.