Igor Shats

This study identifies the host soluble inositol phosphate pathway as critical for coronavirus replication and demonstrates a multi-target inhibitor that effectively suppresses viral replication in cells and mice.

The paper builds predictive models for drug sensitivity using gene expression data from cancer cell lines and applies them to predict drug responses in tumor and normal tissues.

This paper introduces CDSeq, a computational method that estimates both cell type proportions and gene expression profiles from bulk RNA-seq data, outperforming existing methods in accuracy.