Melanie Schirmer

MetaGEAR Explorer enables cross-cohort microbiome analyses to identify disease-associated microbial genes by expanding gene searches beyond sequence similarity.

The paper investigates how probiotic interventions in infants affect bacterial strain dynamics and immune responses, finding that specific strains are displaced regardless of IgA binding.

The paper compiles 2,658 Desulfovibrio genomes from 90 diseases and 32 countries to identify species-specific functional traits linked to inflammatory diseases.

The paper develops MetaGEAR, a gene-centric metagenomic analysis framework, to investigate microbiome functionality in diseases and identify disease signature genes and mobile genetic elements.

The paper identifies oral-gut microbial translocation in ACLD patients linked to intestinal barrier dysfunction and hepatic fibrosis, with prtC encoding bacteria as a biomarker.

The paper develops MMUPHin for meta-analysis of microbial communities in IBD, identifying consistent microbial associations and showing no discrete microbiome types.