Shen Jin

MetaGEAR Explorer: rapid interactive searches and cross-cohort microbiome analyses to identify disease associations of microbial genes

MetaGEAR Explorer enables cross-cohort microbiome analyses to identify disease-associated microbial genes by expanding gene searches beyond sequence similarity.

Extensive genomic diversity in Desulfovibrio species reveals species-specific functional traits associated with disease

The paper compiles 2,658 Desulfovibrio genomes from 90 diseases and 32 countries to identify species-specific functional traits linked to inflammatory diseases.

Gene-centric metagenomic analyses reveal microbiome functional insights into diseases

The paper develops MetaGEAR, a gene-centric metagenomic analysis framework, to investigate microbiome functionality in diseases and identify disease signature genes and mobile genetic elements.

Microbial oral-gut translocation in advanced chronic liver disease is linked to exacerbation of intestinal barrier dysfunction and hepatic fibrosis

The paper identifies oral-gut microbial translocation in ACLD patients linked to intestinal barrier dysfunction and hepatic fibrosis, with prtC encoding bacteria as a biomarker.