Wayne G. Shreffler

This study shows that gut and oral bacteria metabolize peanut allergens, affecting IgE-binding and anaphylaxis severity in allergic individuals.

The paper identifies GPR15+ CD38+ peripheral blood Th2 cells associated with active eosinophilic esophagitis, showing potential as a non-invasive biomarker and suggesting new disease mechanisms.

This companion paper identifies a β-casein-specific TCR clonotype and its HLA restriction in a patient with EoE milk allergy, supporting findings from the parent study.

The study identifies IgE+ memory B cells in humans as rare and suggests their limited clinical utility in allergic disease.