Author

Jean‐Frédéric Colombel

Icahn School of Medicine at Mount SinaiORCID 0000-0001-6472-249XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Miriam MéradiD· 2 shared Aaron M. EtraiD· 1 shared Andreas SchlitzeriD· 1 shared Andrew E. DavisiD· 1 shared Ángela Sanzo-MachucaiD· 1 shared Anuk Das· 1 shared Ari Grinspan· 1 shared Arnaud BourreilleiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Miriam MéradORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintFeb 13, 2026

A JAK-STAT-activated myeloid hub at ulceration sites underlies resistance to anti-TNF therapy in Crohn's disease

Thomas Laurent, Monika Mykhaylyshyn, Jake Thomas…·J. P. D. Martin

The paper identifies a JAK-STAT-activated myeloid subset, IFIM, associated with anti-TNF resistance in Crohn's disease and proposes JAK inhibition as a therapeutic strategy.

DOI 10.64898/2026.02.12.705345

humanscRNA-seq

𝕏 PostBluesky

ImmunologyGutPeer-reviewedFeb 17, 2025

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

Daniela Guisado, Sayali Talware, Xiaoli Wang…·Louis Cohen

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

9 citationstop 4%

humanscRNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintMar 6, 2018

Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice

Graham J. Britton, Eduardo J. Contijoch, Ilaria Mogno…·Jeremiah J. Faith

The paper shows that IBD microbiotas alter gut CD4 T-cell balance and drive colitis in mice, with specific T-cell profiles predicting disease status and severity.

DOI 10.1101/276774

mousebulk RNA-seq

𝕏 PostBluesky