Jeremiah J. Faith

Bacteroidetes promote hepatocellular carcinoma progression and resistance to immunotherapy

This study identifies Bacteroidetes enrichment as a biomarker of immunotherapy resistance in hepatocellular carcinoma and shows its pro-tumorigenic effects in mouse models.

Long read metagenomics-based precise tracking of bacterial strains and genomic changes after fecal microbiota transplantation

This study introduces LongTrack, a long-read metagenomics framework for precise strain tracking in FMT, revealing genomic changes in engrafted bacteria over time.

Cooperation Between Genotoxic Bacteria Accelerates Tumorigenesis in a Mouse Model of Colon Carcinogenesis

The paper shows that genotoxic bacteria in the gut accelerate colon cancer in mice, regardless of donor health status.

Inflammatory disease microbiomes share a functional pathogenicity predicted by C-reactive protein

The paper investigates shared and distinct functional pathogenicity of gut microbiomes in inflammatory diseases using germ-free mice colonized with human fecal samples.

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells

This study shows that IL-23-induced pathology in newborn mice is mediated by IL-22, which disrupts pancreatic and intestinal cell function, leading to malabsorption and early death.

Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice

The paper shows that IBD microbiotas alter gut CD4 T-cell balance and drive colitis in mice, with specific T-cell profiles predicting disease status and severity.