Inflammatory bowel disease microbiotas alter gut CD4 T-cell homeostasis and drive colitis in mice
Graham J. Britton, Eduardo J. Contijoch, Ilaria Mogno, Olivia H. Vennaro, Sean R. Llewellyn, Ruby Ng, Zhihua Li, Arthur Mortha, Miriam Merad, Anuk Das, Dirk Gevers, Dermot P.B. McGovern, Namita Singh, Jonathan Braun, Jonathan P. Jacobs, , Jeremiah J. Faith
The paper shows that IBD microbiotas alter gut CD4 T-cell balance and drive colitis in mice, with specific T-cell profiles predicting disease status and severity.
bioRxiv · Mar 6, 2018 · PreprintImmunology