NeurosciencebioRxivPreprint
Expression of a modified astrocytic glutamate transporter alleviates Huntington hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions
Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad…·Rosemarie Grantyn
This study shows that modifying the C-terminal of EAAT2 in a Huntington's disease mouse model reduces hypokinesia symptoms by improving glutamate clearance and reversing some HD-induced changes in EAAT2 interactions.
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