Rosemarie Grantyn

Expression of a modified astrocytic glutamate transporter alleviates Huntington hypokinesia, promotes synaptic glutamate clearance and counteracts potentially adverse EAAT2 interactions

This study shows that modifying the C-terminal of EAAT2 in a Huntington's disease mouse model reduces hypokinesia symptoms by improving glutamate clearance and reversing some HD-induced changes in EAAT2 interactions.

Single synapse indicators of impaired glutamate clearance derived from fast iGluu imaging of cortical afferents in the striatum of normal and Huntington (Q175) mice

The paper uses iGluu imaging to analyze glutamate clearance at single synapses in Huntington's disease mice, finding impaired uptake and release in affected synapses.