Dietmar Schmitz

This study shows that autoantibodies against GABAB receptors cause presynaptic pathology leading to cognitive decline and memory impairment.

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

This study finds that recurrent seizures in epilepsy are associated with reduced cortical entropy in the interictal state, particularly in those with earlier seizure onset.

The paper identifies an intrathecal antibody response to EBV BRRF2 and human antigens in MS, showing cross-reactivity and association with increased IgG synthesis.

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

The paper shows that inhibitory topology determines the spatial organization of hippocampal sharp-wave ripples, while inhibitory activity governs their dynamics.

The paper uses mRNA-engineered dendritic cells to detect AQP4-specific T cell responses in NMOSD patients, showing strong activation in a patient with recent disease activity.

This paper introduces two tangential insertion methods for high-density silicone probes in head-fixed mice to improve spatial sampling of hippocampal activity.

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

The paper shows that sequential visual flickering increases high-frequency power in the visual cortex of mice.

This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.

The paper introduces PinkyCaMP, a new red fluorescent calcium sensor with improved brightness, photostability, and compatibility with optogenetics and neurotransmitter imaging.

This study identifies Nurr1 as a critical transcription factor for claustrum development and function, showing its role in neuronal positioning and behavior regulation.

The paper characterizes neuronal and synaptic diversity in human layer 2-3 pyramidal neurons across individuals, finding that neuronal physiology varies with laminar depth while synaptic properties are consistent.

The paper investigates the role of Calbindin-containing CA1 pyramidal cells in cognitive flexibility during spatial tasks in mice, finding they support adaptation to environmental changes.

The paper investigates cAMP-dependent synaptic plasticity in mouse hippocampal CA1 and finds hemisphere-specific potentiation at commissural synapses from the right hemisphere.

The paper explores how nonlinear dendritic integration in PV+ basket cells modulates hippocampal oscillations through bimodal dendritic strategies.

This study shows that complex learning abilities can be inherited through epigenetic modifications in the mammalian brain, as offspring of trained rodents exhibit enhanced neuronal excitability and DNA methylation changes.

This study shows binge feeding increases food intake by suppressing olfactory flavor representation in the anterior piriform cortex through specific neuronal activity patterns.

The paper investigates connectivity between thorny and athorny CA3 pyramidal neurons and finds asymmetric input patterns that may explain their sequential activation during sharp waves.

The paper identifies ultraslow serotonin oscillations in the hippocampus that distinguish substates within NREM and waking, linking them to memory consolidation and arousal.

This study identifies Piccolo's role in astrocytic ECM secretion, showing its impact on synapse formation and neuronal network activity in PCH3.

This study shows that mice do not uniformly express defensive behaviors when exposed to predators, instead showing context-dependent and variable responses.

This study identifies distinct roles of cortical layer 5 IT and ET neurons in associative learning using transgenic mice and calcium imaging.

This study investigates the role of synapsin isoforms in presynaptic plasticity at hippocampal mossy fiber boutons in male mice, finding decreased short-term and increased long-term plasticity upon synapsin deletion.

This paper identifies PdCO as a bistable GPCR with high temporal precision for optogenetic control of neural circuits in vivo.

The paper demonstrates that gamma-oscillation plasticity in the hippocampus is mediated by parvalbumin interneurons through specific metabotropic signaling pathways.

The paper analyzes ripple propagation in the hippocampus using mouse recordings and finds that strong ripples originate from the septal pole and propagate differently based on their generation location.

The paper identifies primate-specific CAMK2B splice variants regulated by branch point weakening, showing their role in long-term potentiation and learning.

The paper demonstrates that patient-derived monoclonal GABAA receptor antibodies cause catatonia and seizures in rodents, providing a model for autoimmune encephalitis and supporting antibody depletion as a treatment.